Sunday, May 18, 2014

1. Gilbert's- Tbili will often be <3, with direct bili <0.3
Acute cholecystitis- Tbili usually <2 (cholangitis may be higher)
2. Pancreatitis:
- Parental nutrition (esp PPN) has super high infection rate. Enteral feeding if at all possible.
- Antibiotics only indicated with necrotic pancreatitis (IV contrast CT-- pancreatic tissue that doesn't enhance is necrotic)
3. Manage erosive esophagitis (thought to be 2/2 GERD) with PPI
4. Indications for endoscopy in someone with dyspepsia (i.e. "alarm signs")
- Weight loss
- Dysphagia
- Odynophagia
- Unexplained iron deficiency anemia
- Jaundice
- Age over 55 (because incidence of gastric cancer is higher)
5. Differential for multiple nodular opacities concentrated in the upper lobes on CXR
- Granulomatous infection (TB, histo, blasto)
- Localized bronchiectasis with mucous plugging (tubes can look like nodules if shot at obliquely) - ABPA, which occurs in asthmatics. CF tends to produce more distributed bronchiectasis and is an unlikely diagnosis in an older person
- Much less likely - cancer. Metastatic disease tends to be more evenly distributed and if anything concentrates in the lower lobes as there is more blood flow, and it would be unusual to have dozens of primaries.
6. Critical care learning:
http://www.aic.cuhk.edu.hk/web8/Renal.htm
7. Screening for hepatocellular carcinoma
- Abdominal u/s + aFP > 500 is diagnostic without a biopsy
- You can develop HCC in hep B without cirrhosis.
8. Primary Biliary Cirrhosis
- Occurs predominantly in women (80-90%), typically aged 40-60
- Diagnostic triad: cholestatic liver profile, +Antimitochondria antibody, liver bx
- Alk phos is often 10x normal
- Normal alk phos and negative antimitochondria ab => look for a different disease.
9. Microscopic colitis: 
- Older people
- Nonbloody diarrhea
- Macroscopically normal
- Histology shows either increased intraepithelial lymphocytes (lymphocytic colitis) or increased submucosal collagen layer (collagenous colitis)
- Typical onset is 60s for collagenous, 70s for lymphocytic. Affects women more than men
10. Crohn's disease in the small bowel can present as non-bloody diarrhea.

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