CNS Lymphoma

General
- Primary Sporadic extranodal lymphoma (older patients) - usually EBV-neg - no extra-CNS disease
- Primary CNS lymphoma of immunocompromised patients - can occur at any age - usually EBV-associated
- Secondary CNS lymphoma = mets from primary lymphoma elsewhere, most common - 2/3 leptomeningeal/subependymal disease
- Single/multiple lesions, or diffuse infiltrate
- Mostly large B-cell lymphomas
- Tx with intrathecal chemo and RT
- Poor prognosis


Path:

(source: Dr.Pytel's CNS tumors lecture)
- no processes emanating from cells


Imaging: 
- Data and images sourced from this AJNR paper
- Immunocompetent: usually homogenously enhancing (90%), ring-enhancing (0-13%)
- AIDS patients - heterogenously enhancing 75% of the time

- homogenously enhancing, can be dural-based 

- AIDS related disease - can be heterogenous, ring-enhancing