Saturday, June 7, 2014

1. Polyradiculoneuropathies 
- Diagnose with CSF
- West nile
- Guillian Barre
- HIV
- CMV
- Carinomatous or lymphomatous nerve root invasion
2. Guillian Barre
- CSF: nl cell count, elevated protein
- Symptoms peak 4 weeks after onset
- Treat with IVIg and plasma exchange-- both equally efficacious
3. Likelihood ratios of 2, 5 and 10 increase probability of having a disease by 15, 30, and 45% respectively.
4. Indication for live influenza virus: 
- Age 5 to 49
- No chronic diseases
- Not immunosuppressed (incl chemo/rad/steroids/TNF-a drugs)
- Not living with an immunosuppressed person
- Not pregnant
- Doesn't have active, untreated TB
5. Zoster vaccine
- Indicated in anyone over 60
- Reduces incidence of zoster by 51% and of postherpetic neuralgia by 67%
- More effective in reducing disease in people aged 60-69, but reduces postherpetic neuralgia more in people age 70+
- Everyone should be vaccinated regardless of their antibody status
- However this is a live vaccine so the standard CI to live vaccines hold (see #4 on this list)
6. Tetanus vaccination and wounds
- if you have a wound and unclear/incomplete tetanus vaccination history -- complete TDaP series + tetanus immune globulin
- If no tetanus booster in the last 5 years and the wound looks bad -- TDaP booster
- If no tetanus booster in the last 10 years and the wound looks clean -- TDaP booster
7. Early stage breast cancer:
- <2cm tumor, no lymph node involvement, no sentinel node involvement
- Negative sentinel node has a high NPV, so there's no need for a full axillary dissection
- Whole body PET scan has a PPV of 1% in this population-- lots of false positives, so its not indicated.
8. Screening for colorectal cancer in high risk patients: 
- 1st degree family member with colorectal cancer: increases odds of colorectal cancer by 2-3 times. That risk doubles again if the family member was diagnosed before age 45. If two people in the family got diagnosed, the risk goes up to 20%.
- For people with a first degree relative with colon cancer, screening colonoscopy should happen at age 40 or 10 years before the family member got diagnosed, and then at 3-5 year intervals afterwards.
- For IBD patients, the annual cancer risk in people with extensive colitis is 0.5% per year. Screening should start 8 years after diagnosis and continue every 1 to 2 years afterwards.
9. Incidental small lung nodules
- For nodules <3mm, risk of cancer is 0.2%, and 4-7mm risk os 0.9%
- For an incidental nodule <4mm, no further follow up if the patient is low risk, and repeat CT in 12 months if they are higher risk for lung cancer.
10. If there is suspected advanced/metastatic lung cancer (i.e. +supraclavicular LN) you should biopsy the suspected mets, which will both diagnose and stage the cancer.

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