Friday, September 6, 2013

1. Kocher criteria for septic joint: 
-Non weight bearing
-ESR>40 (alt: CRP>20)
-T>101.5/38.5
-WBC>12
1/2/3/4 criteria correspond with 3/40/93/99 percent chance of septic joint
2. Acute onset of limping in a child: ddx
-transient synovitis (postviral)
-septic joint (see kocher criteria)
-leukemia
-osteosarcoma/mets (older kid)
-avascular necrosis of femoral head 2/2 legg-calve-perthes, steroids, sickle cell, gaucher, alcohol, lupus. Note: younger kids have dual blood supply to femur (foveal aa) that eventually closes, and so are less likely to get avasc necrosis.
3. Ativan toxicity: 
-BP/RR/mental status: often go down
-HR can go up or down, same with bowel sounds/pupils
adults will show hyporeflexia, kids can be obtunded.
4. In ingestions with significant pill burdens, the pills can coalesce and form a pill bezoar in the stomach, leading to release of drug over long time.
5. Aminglycosides can have a post-antibiotic effect, whereby they continue to kill bugs even after their blood levels drop to undetectable (adults estim ~4 hours, younger kids ~8). For maximal effectiveness in CF patients, you want a really high peak to increase absorption into tissues (fibrotic lungs) and to be significantly higher than MIC. Watch peaks on patients that are pregnant/burn patients who have different volumes of distribution.
6. Berlin heart: extracardiac pump, b/l assist, bridge to transplant in kids. Outcomes after 2 years in one study: 26% death, 60% transplant, 5% weaned, 8% still on device. Preferable to ECMO because lower surface area requires less heparin, lower risk of intracranial bleed. Preferable to LVAD because bilateral assist, kids' rib cages have limited space.
7. In someone who is tachypneic (like asthma) you expect blood gases to show respiratory alkalosis, with low CO2s (20s) and pH somewhere around 7.45-7.5. If you see an asthmatic kid, breathing fast and with a "normal" blood gas, i.e. pH 7.4 and CO2 of 40, that means they are retaining CO2, not doing good gas exchange.
8. Azithromycin has immunomodulating effects, as well as antibiotic. It can increase neutrophil apoptosis, decrease neutrophil migration; it has been shown to decrease eosinophils in the sputum of asthmatics and even decrease bronchial hyperreactivity.
9. Linezolid: thrombocytopenia, serotonin effects that can lead to serotonin syndrome in combo with other drugs.
10. Pedi meds that taste bad: flagyl, penicillin V, ferrous sulfate, linezolid, prendnisolone...

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