1. SNRIs: 
-Desvenlafaxine (pristiq)

-Milnasaprine (sevena) - fda approved for fibromyalgia 

-Levomilnasaprine- FDA approved for depression 

-Venlafaxine (effexor) - causes clinically significant hypertension, better sexual side effects, worse somatic side ffects
-Duloxetine (cymbalta)- 60 cases of fulminant hepatic failure reported. Good for concomitant pain. 

2. Atypical antidepressants: Bupropion 
-dopamine and norepinephrine.

-Extended release formulas have much lower risk of seizures. In first trials for bullemia, 20% of the first 50 patients seized. 

-Can worsen anxiety in some people, esp those who are sensitive to caffeine. Some psychiatrists will not prescribe this in people who have depression with a significant anxiety component. 

-Does not cause sexual side effects. 

-Good for amotivational depression, seasonal affective disorder. 

3. Atypical antidepressants: Trazodone

-very sedating;  at low doses, hypnotic with no addiction. good as an add-on to treat depression-associated insomnia 

-Does not restore sleep architecture. 

4. Atypical antidepressants: Mirtazapine:
-restores sleep architecture so you get good restorative sleep (z-drugs and trazodone do not). 

-Potent antihistamine; the sedation and weight gain are significant. 

-Can cause leukopenia.
-More sedating at lower doses (~15) Less sedating at higher doses (>30), may be due to increased a2-antagonism at higher doses leading to norepi release  

5. Other strange antidepressants: 
-Nefazodone: black box warning for hepatic failure
-Velazadone (viibryd): has SSRI action and partial agonism of 5HT-1A, similar to buspar 

-Vortioxetine: also SSRI + 5HT-1A 

6. Stimulants: 

-worsen anxiety.
-contraindicated in structural heart dx.
-Work extremely will, if you fail one, 50% chance you'll respond to the other
-Monitor weight and height in kids.
-Prob do not cause heart problems
-Dexedrine - diet pill in 60s/70s
-Only sometimes exacerbate tic disorders, will sometimes bring out new ones 

7. Benzo: Clonazepam (klonopin)

-long half life (24 hrs) slow onset 

-good for long term treatment of panic disorders, short term treatment of anxiety (<2-3 mos; longer: choose SSRI)

8. Benzo: Diazepam (valium)

-Long half life (100 hrs 2/2 active metabolite oxazepam), rapid onset

-Good for alcohol detox: drops symptoms quickly, stays around to self wean

9. Benzo: Lorazepam (ativan)

-Medium half life (8-12 hrs), onset in ~30 minutes. 

-Good for panic attacks, short-term anxiety management, alcohol withdrawal. 

-Ativan + haldol: great combo for dealing with people going crazy in the ER

10. Benzo: Alprazolam (xanax)

-Short half life (3-4 hrs), very fast onset. 

-Addictive

-Highest street value