Thursday, January 23, 2014

1. Competence to stand trial (all four required):
-Understand charges against them
-Able to work with lawyer
-Understand consequences on their life/values of the different outcomes
-Able to testify.
2. Not guilty by reason of  insanity criteria
-have mental illness
-not understand right from wrong
-not understand consequences of actions
at the time of action.
Then must meet one of the following criteria (depending on state): M'Naghten, American Law Institute Moral Penal Code
3. WBC & psychotropic drugs:
-Lithium: benign leukopenia
-Depakote: benign thrombocytopenia, agranulocytosis (rare)
-Carbamazepine: agranulocytosis
-All anti-psychotics: tranisent drop in leukopoesis, more common in clozapine
4. Schizotypal personality disorder: 
-Hallucinations rare
-May be confused with schizophrenia in remission
-Treat concomitant psychotic, mood, or anxiety symptoms with neuroleptics, SSRIs, and benzos respectively; these people do not have the insight and focus to benefit from therapy, esp if floridly psychotic.
-Vs paranoid personality disorder: both can have paranoia, withdrawal from people; however schizotypal's paranoias are a little more "magical" and odd, while paranoid personality disorders' suspicions are more grounded in reality.
5. Physiologic effects of alcoholism:
-Peripheral neuropathy (dietary micronutrient deficiencies, passing out drunk in bad positions)
-Decreased hematopoesis (thrombocytopenia, macrocytic anemia)
-Leukopenia/compromised T cell function
-Hepatitis/Cirrhosis (follow LFTs initially, PT-INR later)
6. Good tests to assess for delirium-- go-no-go and 1A2B.... counting, as they require high frontal lobe functioning.
7. Benzodiazepines can worsen lung function in those with chronic severe pulmonary disease.
8. Management of alcohol withdrawal:
-Good liver function: long-acting benzodiazepams, like cholordiazepoxide (librium) and diazepam (valium)
-Poor liver function, old person: shorter-acting benzos, like lorazepam, oxazepam
9. Panic attacks rarely lead to syncope- if a person is describing a panic attack like event and they syncopized, cardiovascular pathology is more likely and should be worked up.
10. Drug detox: 
-For opiate detox, try clonidine before methadone
-In suspected sedative overdose, give thiamine, dextrose, naloxone but not flumazenil unless you are sure they took benzodiazepines, as it can hypothetically decrease the seizure threshold.

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